Posts by Collection

Sound Reasoning: Auditory Representations of Mathematical Concepts

Published: November 18, 2024

Mathematical reasoning through auditory representations of statistical distributions

Mapping the Statistics of the Human B cell system

A systems-level view of B cells

By sampling B cells from multiple hard-to-study organs within the same individual, Ivana Cvijovic and I generated the first systems-level perspective of the human antibody system. Most immune-monitoring efforts focus on the peripheral blood because it is non-invasive. Our study compares as many as 5 organs per donor, which allows systematic insights into the dynamics of long-term antibody memory in Humans and informs non-invasive immune monitoring.

Key findings:

• Long-term antibody memory emerges uniformly throughout the immune response
• Proliferative antibody-secreting cells uniquely circulate among multiple tissues
• Immune-monitoring via the peripheral blood has key sampling biases and limitations

Read the full paper

Leveraging lineage tracing to understand cell reprogramming

This study investigates how cells integrate external signals with their intrinsic state during reprogramming, using human B cells as a model system.

This study investigates how cells integrate external signals with their intrinsic state during reprogramming, using human B cells as a model system.

Key findings:

• Intrinsic cellular states significantly influence reprogramming outcomes
• Reprogrammed cell populations show high diversity in final states
• Cells from the same lineage (clones) often adopt similar fates, indicating the importance of initial cell state

These results have important implications for cell-based therapies and tissue engineering. Intrinsic heterogeneity in the input cells should be understood and harnessed for better outcomes.

Creating the datasets to enable Molecular Medicine

As a key contributor to the Tabula Sapiens Consortium, I’ve helped create a multi-organ, single-cell transcriptomic atlas of humans. This atlas serves as a valuable resource for training foundation models of biology and understanding the molecular basis of diseases.

As a key contributor to the Tabula Sapiens Consortium, I’ve helped create a multi-organ, single-cell transcriptomic atlas of humans. This atlas serves as a valuable resource for training foundation models of biology and understanding the molecular basis of diseases.

My contributions include:

• Procuring organs
• Processing tissues into single-cell suspensions
• Preparing sequencing libraries
• Analyzing vast datasets

Research focus: Analyzing immune cells across tissues to gain new insights into this complex system’s function and regulation within the context of the broader human atlas.

Read the full paper

leveraging my n-of-one neural network to advance the state of chillwave

I make ambient chillwave music under the name maiklo.

re:mixing Line Drawings with AI

using the Dall-E API